Effects of phosphatidylserine in Alzheimer's disease
Crook, T.; Petrie, W.; Wells, C.; Massari, D.C.
Psychopharmacology Bulletin 28(1): 61-66
1992
ISSN/ISBN: 0048-5764 PMID: 1609044 Document Number: 404343
We studied 51 patients meeting clinical criteria for probable Alzheimer's disease (AD). Patients were treated for 12 weeks with a formulation of bovine cortex phosphatidylserine (BC-PS; 100 mg t.i.d.) or placebo, and those treated with the drug improved on several cognitive measures relative to those administered placebo. Differences between treatment groups were most apparent among patients with less severe cognitive impairment. Results suggest that phosphatidylserine may be a promising candidate for study in the early stages of AD.