Platelet receptors: nomenclature--structure--function. 1
Beer, J.H.
Schweizerische Medizinische Wochenschrift 122(34): 1249-1263
1992
ISSN/ISBN: 0036-7672 PMID: 1326787 Document Number: 404279
Current knowledge on platelet receptors, their structure, function and interaction with their ligands, and the various nomenclatures, is summarized. The role of platelet receptors in thrombosis and hemostasis, and in cell adhesion and invasion, is discussed. Many of the receptors are members of large families of cell-adhesion molecules (such as the integrin family of cell-adhesion receptors) and have common subunits. While some receptors are exclusive to platelets and megakaryocytes (e.g. GP IIb/IIIa), others may be found on several other cell types (such as the receptors for epinephrine or vitronectin). In addition, the receptors for the most important platelet agonists and the platelet binding sites of factors of plasmatic coagulation and fibrinolysis are reviewed.