Histopathological and histochemical studies on the sigmoidal and rectal tissues of hepatosplenic children with gastro-intestinal troubles
Mangoud, A.M.; Nasr, A.N.; Farrag, A.I.; Badr, M.A.; el Mahrouky, F.E.; Hassan, S.A.; Salama, M.M.; Morsy, T.A.
Journal of the Egyptian Society of Parasitology 22(3): 643-652
1992
ISSN/ISBN: 1110-0583 PMID: 1431283 Document Number: 404002
Hepatosplenomegaly accompanied with different intestinal troubles is more or less a marked clinical manifestations in children. The histopathological and histochemical changes were studied in biopsied materials taken from the sigmoidal and rectal tissues of 49 children. These children had schistosomiasis mansoni (26), schistosomiasis and amoebiasis (4), schistosomiasis and tuberculosis (TB.) (2), amoebiasis (4), thalassemia (6), acute myeloid leukaemia (AML) (1), mucopolysaccharidosis (1) and bacillary dysentery (5). The pathological changes were erosion, ulceration, hyperplasia, atrophy, crypt-abscess and fibrosis (mucosa) and oedema, congestion, cellular infiltration (Lamina propria). The chemical changes were the mucin secretion, deposition of collagen and fibrin and activity of the argentaffin cells. Not all the disease agent had the same effect, but changes were marked mainly in children with Schistosoma mansoni and/or Entamoeba histolytica.