The effect of nizoral on the function of the hypothalamo-hypophyseal-ovarian system in virilism
Manusharova, R.A.
Likars'ka Sprava 8: 89-91
1992
ISSN/ISBN: 1019-5297 PMID: 1475939 Document Number: 403796
A study is presented of the effect of nisoral on the hypothalamo-pituitary-ovarian system in 25 patients with hyperandrogenism (ovarian in 11, suprarenal in 14). It was established that most patients with oligomenorrhea and anovulation showed a restoration of the menstrual cycle after the 2-3 treatment courses and also absence of progression and reduction of the rate of pathological hair growth. After nisoral treatment the testosterone level decreased while estradiol and progesterone increased, gonadotropins remained unchanged, urinary excretion of 17-ketosteroids reduced.