Lymphoid interstitial pneumonia not associated with HIV infection: role of Epstein-Barr virus
Malamou-Mitsi, V.; Tsai, M.M.; Gal, A.A.; Koss, M.N.; O'Leary, T.J.
Modern Pathology An Official Journal of the United States and Canadian Academy of Pathology Inc 5(5): 487-491
1992
ISSN/ISBN: 0893-3952 PMID: 1344810 Document Number: 403520
The polymerase chain reaction (PCR) method was used to determine the presence of Epstein-Barr virus sequences in seven cases of pulmonary lymphoid interstitial pneumonia not associated with HIV infection. Evidence of Epstein-Barr virus genome was found in three of six cases in which beta-globin gene, used as an internal control for the integrity and amplifiability of the tissue DNA, could be detected. These results suggest that Epstein-Barr virus infection is not always required for the development of lymphoid interstitial pneumonia.