Leopard spot chorioretinopathy. Initial manifestation of recurrent acute lymphocytic leukemia
Schimmelpfennig, W.; Aur, R.J.
Der Ophthalmologe Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 89(5): 430-431
1992
ISSN/ISBN: 0941-293X PMID: 1304225 Document Number: 403469
An 11-year-old girl with a history of acute lymphocytic leukemia of the central nervous system had attained complete remission for almost 3 1/2 years after combination chemotherapy and radiotherapy when she developed iritis and chorioretinopathy of the right eye. Neither an anterior chamber tap nor a diagnostic vitrectomy revealed leukemic cells. Both nonspecific anti-inflammatory therapy and antiviral treatment were unsuccessful. Finally, lymphoblasts were detected in the cerebrospinal fluid and in the bone marrow after repeated lumbar puncture and bone marrow aspiration. Combination chemotherapy alone was resumed, resulting in the resolution of all acute ocular symptoms and bone marrow involvement. Only the leopard-spot-like pigmentary fundus changes persisted. The child has now remained in continuous complete remission for 1 1/2 years.