Acute aflatoxin B1 toxicity in the macaque and its similarities to Reye&apos;s syndrome

Bourgeois, C.H.; Shank, R.C.; Grossman, R.A.; Johnsen, D.O.; Wooding, W.L.; Chandavimol, P.; Bourgeois, C.H; Shank, R.C; Grossman, R.A; Johnsen, D.O; Wooding, W.L; Chandavimol, P

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Acute aflatoxin B1 toxicity in the macaque and its similarities to Reye's syndrome

Bourgeois, C.H.; Shank, R.C.; Grossman, R.A.; Johnsen, D.O.; Wooding, W.L.; Chandavimol, P.

Laboratory Investigation; A Journal of Technical Methods and Pathology 24(3): 206-216

1971

ISSN/ISBN: 0023-6837

PMID: 4994463

Document Number: 40311

Eighteen monkeys were given various doses of chromatographically pure aflatoxin B1. Death occurred in one animal receiving 4.5 and in all animals receiving 13.5 mg/kg or more. Cough, vomiting, diarrhoea and coma were characteristic clinical findings.