Studies on the mechanisms of HTLV-i leukemogenesis
Saggioro, D.; Majone, F.; Forino, M.; Turchetto, L.; Chieco-Bianchi, L.
Leukemia 6(Suppl 3): 64s-66s
1992
ISSN/ISBN: 0887-6924 PMID: 1602829 Document Number: 402869
The factors that regulate low viral expression and long latency after HTLV-I infection are poorly understood. To study the possible mechanisms involved in the regulation of gene expression and cell transformation, we studied whether (1) methylation could play a role in viral transcription, and (2) tax product could favor chromosomal instability. The results indicate that methylation of HTLV-I LTRs blocks their transcriptional activity and that tax protein triggers DNA damage.
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