Role of iron in the virulence of Vibrio vulnificus isolated from Cuddalore coastal waters (India)
Jayalakshmi, S.; Venugopalan, V.K.
Indian Journal of Medical Research 95: 294-296
1992
ISSN/ISBN: 0019-5340 PMID: 1291464 Document Number: 402279
V. vulnificus strains isolated fron different sources of Cuddalore coastal waters were tested for their virulence activity through their LD-50 values in mice. As infections of V. vulnificus have been correlated with pre-existing liver disease and hemochromotosis, the role of iron on virulence was determined using, iron overloaded mice. The LD-50 was in the range of 10-4-10-7 cells in normal mice but 10-1-10-2 cells in iron-injected mice, thus providing evidence that iron may play a major role in the pathogenesis of V. vulnificus.