Tensides from the group of propylene oxide and ethylene oxide copolymers. X. Solubilization of acetylsalicylic acid by polyetherodiol micelles
Zgoda, M.M.
Acta Poloniae Pharmaceutica 49(4): 93-98
1992
ISSN/ISBN: 0001-6837 PMID: 16092443 Document Number: 401590
The process of structural solubilization of acetylsalicylic acid in balanced systems (weight-balanced) by micelles of Rokopols of 30p160 and 30p60 types and, for comparison, by those of F-68 and F-108 Pluronics was investigated. The determined viscosity and hydrodynamic parameters allowed for the calculation of solubilizing activity of polyetherodiol micelles--n(s(A)). The results of the investigation point at Rokopols as an excipient, which may help to obtain new drug delivery systems.