A study of vitamin inhibition on the mutagenicity of the antineoplastic drugs
Zhao, Z.Z.; Huang, M.T.
Zhonghua Yu Fang Yi Xue Za Zhi 26(5): 291-293
1992
ISSN/ISBN: 0253-9624 PMID: 1298607 Document Number: 401103
The inhibitory effects on the mutational specificity of antineo-plastic drugs of 14 kinds of vitamin were tested with the method of mutational and antimutational synchoronous test, add S-9 and no S-9. Vit C, Vit B-6, and nicotinic acid had distinct inhibitory effects on the mutational specificity of 6 antineoplastic drugs, namely, mitomy-cin C, bleomycinia, fluorouracili, cis-Diaminodichloroplatinum, arabinosylcytosini and mustargen Vit K-3 showed inhibitory effect to mitomycin C, fluonouracili, cis-diaminodichloroplatinum, and arabinosylcytosini, but Vit AD, VIT B-1, Vit B-2, Vit B-co, Vit D-3, Vit E, Rutin, VIt K-1, Vit K-4 and folic acid did not. The fact that Vit C, vit B-6, nicotinic acid and Vit K-3 showed anti-mutational effects is of some significance with reference to clinical therapeutic and prevention of tumours.