A comparative analysis of the action of oxidative metabolic inhibitors on the luminescence parameters of normal and tumorous cells
Lebedev, O.E.; Sergeenko, N.G.; Sal'nikov, K.V.; Barskiĭ, I.I.
Tsitologiia 34(3): 39-45
1992
ISSN/ISBN: 0041-3771 PMID: 1440928 Document Number: 400202
Comparative investigation of different mitochondrial oxidative metabolism inhibitors action on NAD(P)H and flavoproteins fluorescence intensity of minimal transformed 3T3 NIH mouse fibroblasts and rat HTC hepatoma cells was made. Principle differences were shown between these cells in oxidized flavoproteins fluorescence intensity changes under the action of used inhibitors. It is suggested that the unusual HTC hepatoma cells flavin fluorescence intensity increase is connected with the oxidation of unidentified flavin-containing component functionally attached to mitochondrial respiratory chain.