Treatment with bifonazole shampoo for seborrhea and seborrheic dermatitis: a randomized, double-blind study
Segal, R.; David, M.; Ingber, A.; Lurie, R.; Sandbank, M.
Acta Dermato-Venereologica 72(6): 454-455
1992
ISSN/ISBN: 0001-5555 PMID: 1362843 Document Number: 399911
A total of 44 patients with seborrhoea and seborrhoeic dermatitis of the scalp, due to Pityrosporum ovale [Malassezia furfur], were treated with either bifonazole shampoo (22 patients) or the vehicle shampoo (22 patients) in a randomized, double-blind vehicle-controlled study. The patients were instructed to wash their scalps 3 times weekly for 6 wks and were examined every 3 wks. Responses were evaluated by clinicians using a clinical grading of scaling, erythema and overall improvement, and also by the patients, who assessed pruritus and overall improvement, using a scale of 0 to 3. The improvement following the bifonazole shampoo was significantly greater than that achieved with the vehicle shampoo with regard to the clinical evaluation of scaling (P=0.01) as well as patient evaluation of pruritus (P=0.008) and overall improvement (P=0.03). No major adverse side effects were recorded.