Effect of Ukrain on the efficacy of anti-epileptic drugs against maximal electroshock-induced seizures in mice
Jagiełło-Wójtowicz, E.; Kleinrok, Z.; Feldo, M.; Chodkowska, A.; Nowicky, J.W.
Drugs under Experimental and Clinical Research 18(Suppl): 107-109
1992
ISSN/ISBN: 0378-6501 PMID: 1305036 Document Number: 399515
It has been found that Ukrain, given intraperitoneally (i.p.), did not influence the threshold for maximal electroconvulsions in mice. Ukrain in doses of 9.5 and 19 mg/kg significantly enhanced the protective efficacy of valproate, decreasing the ED-50 values. However, Ukrain had no effect on the protection provided by diazepam, carbamazepine, diphenylhydantoin and phenobarbital. The combined treatment with Ukrain and anti-epileptic drugs did not cause any signs of toxicity.