Characteristics of pharmacotherapy of rheumatic diseases in advanced age
Breithaupt, H.
Zeitschrift für Rheumatologie 51(6): 301-304
1992
ISSN/ISBN: 0340-1855 PMID: 1481580 Document Number: 399457
Drug treatment in the polymorbid elderly should focus on the more important symptoms. Pharmacokinetic differences should be considered, e.g. a reduced volume of distribution and decreased liver and renal function. Special alterations in the pharmacodynamics with respect to the central nervous system and other organs are important. Drug therapy in the elderly has to be done very cautiously. The indication, dosage and duration of therapy has to be evaluated again and again. Antirheumatics in the elderly should improve the quality of life avoiding untowanted side effects, especially of the gastrointestinal tract, the renal function and bone marrow. Non-narcotic analgesics and opioids may be helpful, when antirheumatics were not tolerated.