Morphohistochemical characterization of suramin--induced chronic toxicity in rat kidney
Soldani, P.; Danesi, R.; Ricciardi, M.P.; Pellegrini, A.; Natale, G.; Paparelli, A.
In Vivo 6(6): 617-620
1992
ISSN/ISBN: 0258-851X PMID: 1296811 Document Number: 398989
The effects of a chronic administration of suramin were evaluated on renal parenchyma of young rats. Animals were given suramin 18 mg/kg i.p. twice a week for two months, a treatment schedule equivalent to that used in cancer patients. At the end of the treatment, suramin concentrations in plasma and kidney were assayed and a morphohistochemical examination of renal parenchyma was carried out. Marked and widespread alterations were detected in both cortex and medulla and were associated with elevated tissue suramin levels exceeding 5 mg/g of tissue. The present data demonstrate that suramin induces a severe chronic renal damage in the rat, associated with high drug tissue levels.