Characterization of G6PD Rohini--a new class IIi Indian variant
Sayyed, Z.; Mukherjee, M.B.; Mudera, V.C.; Colah, R.; Gupte, S.
Indian Journal of Medical Research 96: 96-100
1992
ISSN/ISBN: 0019-5340 PMID: 1428072 Document Number: 398748
A new Indian G6PD variant was detected in a 15 yr old Maratha male during a population screening programme in high school children in Bombay (India). The propositus and two family members having the same variant were apparently healthy. This enzyme variant has a mild erythrocyte G6PD deficiency and a slow electrophoretic mobility. It is characterized by a high Michaelis-Menton constant for G6P, a bimodal curve for pH optima and a slight decrease in the thermostability. The rate of utilization of substrate analogue is similar to that of normal. These observations suggest identification of a new class III variant, designated as G6PD Rohini.