A neuropathological survey of brains submitted under the Bovine Spongiform Encephalopathy Orders in Scotland
Jeffrey, M.
Veterinary Record 131(15): 332-337
1992
ISSN/ISBN: 0042-4900 PMID: 1441143 Document Number: 398218
Bovine spongiform encephalopathy was not confirmed histologically in 225 of 829 bovine brains submitted for diagnosis. Several previously described disorders of the central nervous system were observed in these brains as well as disorders not previously recognised in Britain, including bilateral vacuolation of the substantia nigra, hippocampal sclerosis with brainstem neuronal chromatolysis and necrosis, focal symmetrical encephalomalacia and meningo-angiomatosis. Severe cerebellar dysplasia consistent with pre-natal bovine viral diarrhoea - mucosal disease virus infection or mineralisation of the blood vessels of the basal ganglia were interpreted respectively as congenital changes or changes due to aging and were considered to be of no clinical significance.