Toxic and drug-induced lesions of the pulmonary parenchyma
Russi, E.
Schweizerische Rundschau für Medizin Praxis 81(19): 618-621
1992
ISSN/ISBN: 1013-2058 PMID: 1589677 Document Number: 397958
Pulmonary tissue may be damaged by certain toxins or drugs in a dose-dependent way or by a hypersensitivity reaction. Pathological changes consist of a permeability pulmonary edema, an alveolar hemorrhage, an alveolitis and finally the formation of pulmonary fibrosis. Ingestion of the weed killer paraquat may induce a rapidly progressive and lethal form of fibrosing alveolitis, the inhalation of nitrous oxides may elicit lung edema. The most common drugs causing lung damage are cytotoxic agents, often used in combination, and the noncytotoxic drugs amiodarone and nitrofurantoin.