UV absorption complicates PCR decontamination

Frothingham, R.; Blitchington, R.B.; Lee, D.H.; Greene, R.C.; Wilson, K.H.

Biotechniques 13(2): 208-210

1992


ISSN/ISBN: 0736-6205
PMID: 1389153
Document Number: 397430
UV irradiation is widely used to inactivate contaminating DNA in PCR. Highly UV-absorbent deoxyribonucleoside triphosphates in PCR mixtures reduce the efficiency of UV decontamination. Optimal decontamination may be achieved by irradiating the PCR mixture without the deoxyribonucleoside triphosphates.

Document emailed within 1 workday
Secure & encrypted payments