Penicillin-induced immune-mediated hemolytic anemia in a horse
McConnico, R.S.; Roberts, M.C.; Tompkins, M.
Journal of the American Veterinary Medical Association 201(9): 1402-1403
1992
ISSN/ISBN: 0003-1488 PMID: 1429188 Document Number: 397131
A 5-year-old female American Quarter Horse was determined to have immune-mediated hemolytic anemia after detection of a positive response to a direct Coombs' test. Penicillin-induced immune-mediated hemolytic anemia was confirmed via a direct antiglobulin test, using penicillin-coated RBC. The horse was clinically improved and the anemia resolved in response to supportive care and discontinuation of penicillin treatment. Penicillin should be considered a possible cause of immune-mediated hemolytic anemia in horses.