Use of an in vitro absorption model system for predicting sustained release of verapamil
Neubert, R.; Fahr, F.; Mäder, C.; Lücke, L.; Fries, G.; Rostock, G.
Arzneimittel-Forschung 42(9): 1098-1100
1992
ISSN/ISBN: 0004-4172 PMID: 1445475 Document Number: 396948
It is shown that it is possible to characterize sustained release formulations in vitro using not only dissolution data but also an absorption model system. The mean dissolution time (MDT) has been shown to be a suitable parameter for evaluating sustained release formulations in vitro, t 1/2 and mean residence time (MRT) have been shown to be convenient pharmacokinetics parameters for characterizing sustained release formations. For comparing in vitro and in vivo results the quotients MDT-normal/MDT-retard and MRT-normal/MRT-retard do seem to be useful.