Dynamic changes of pulmonary glucocorticoid receptor in endotoxin-induced lung injury
Liu, L.
Zhonghua Yi Xue Za Zhi 72(8): 468-470; 509
1992
ISSN/ISBN: 0376-2491 PMID: 1337721 Document Number: 396793
The changes of maximal binding capacity (Bmax) of glucocorticoid receptor (GCR) in the endotoxin-induced lung injury were observed by using radioligand binding assay. The content of glucocorticoid (GC) and the activity of phospholipase A2 (PLA2) were also measured. The results showed that the level of GCR in lung cytoplasma decreased continuously after endotoxin infusion, and its affinity decreased in the late phase while PLA2 activity markedly increased. There was a negative correlation between the Bmax of GCR and PLA2 activity (r = -0.87, P < 0.01). These findings indicated that there is a secondary alteration in GCR during endo toxin-induced lung injury, and that the GC hypofunction caused by reduced GCR binding capacity may be of importance in the development of ARDS.