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Age-related changes in mosquito insecticide resistance and their relation to the mechanisms of detoxication

Sergieva, V.P.; Gracheva, G.V.

Meditsinskaia Parazitologiia i Parazitarnye Bolezni 1: 11-15

1992

ISSN/ISBN: 0025-8326
PMID: 1354835
Document Number: 396664
The mechanisms of DDT, permethrin and malathion resistance were determined indirectly by means of synergists inhibiting the detoxification enzymes. It was found that metabolic resistance dependent on glutathione-S-transferase, MFO and carboxylesterase is the most liable to age changes. Such changes are less expressive in mosquitos which have supposedly kdr-resistance. In young mosquitos (1-2 days) of all species, the rate of synergism is relatively low and fails to explain high resistance which is usual for juvenile specimen.

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