Serum gastrin concentrations in colorectal cancer patients
Charnley, R.M.; Thomas, W.M.; Stanley, J.; Morris, D.L.
Annals of the Royal College of Surgeons of England 74(2): 138-40; Discussion 141
1992
ISSN/ISBN: 0035-8843 PMID: 1567134 Document Number: 396218
Fasting serum gastrin concentrations were shown to be elevated in colorectal cancer patients compared with controls (P = 0.0037), which was mainly accounted for by a subgroup of patients who had significantly elevated levels. In cancer patients there was no difference in gastrin concentrations in blood taken from a tumour-draining mesenteric vein and from a peripheral vein at the time of colonic resection. Serum gastrin concentrations were significantly lower after apparently curative resection for colorectal cancer (P = 0.028), suggesting that the elevated serum gastrin seen in these patients may be due, at least in part, to secretion of gastrin by the tumour.