Function, molecular structure and gene expression of granulocyte colony-stimulating factor
Asano, S.
Nihon Rinsho. Japanese Journal of Clinical Medicine 50(8): 1854-1860
1992
ISSN/ISBN: 0047-1852 PMID: 1279238 Document Number: 395698
Human granulocyte colony-stimulating factor, a 19KD glycoprotein consisting of 174 amino acids, is one of the physiological regulators mainly produced by monocytes-macrophages, fibroblasts, and endothelial cells, under various stimulations such as neutropenias and infections. The molecule specifically and markedly stimulates the production of neutrophils associated with an expansion of the hemopoietic stem cells/progenitor cells, proliferates myeloid leukemia cells, releases these cells into blood, and elevates the functional activities of neutrophils. Under the favor of the activities, recombinant human granulocyte colony-stimulating factor has now become an epoch-making agents for the treatment of various disorders.