Hematopoiesis
Smith, S.P.; Yee, G.C.
PharmacoTherapy 12(2 Part 2): 11s-19s
1992
ISSN/ISBN: 0277-0008 PMID: 1598309 Document Number: 395143
Hematopoiesis begins with the pluripotent stem cell in the marrow and culminates in mature, functional red blood cells, white blood cells, and platelets in the circulation. The process consists of a complex and well-orchestrated sequence of cell proliferation, differentiation, and maturation, that is stimulated and regulated by a host of cytokines and hormones. The various growth factors act individually and in concert at different stages of hematopoiesis and have important effects on mature cell function.