Contact allergy to a contaminant in Kathon CG in the guinea pig
Bruze, M.; Gruvberger, B.; Persson, K.
Dermatosen in Beruf und Umwelt. Occupation and Environment 35(5): 165-168
1987
ISSN/ISBN: 0343-2432 PMID: 3691315 Document Number: 3946
Kathon CG is a commercial preservative, consisting of the two active ingredients, 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one (5243-K-CG) and other components. 4,5-dichloro-2-methyl-4-isothiazolin-3-one (45243-K-CG) is a contaminant in Kathon CG. The chemically related active ingredients are known to be contact sensitizers in humans and guinea pigs. Aims of this study were to determine the sensitizing capacity of this contaminant and also to investigate the cross-reaction pattern by guinea pig sensitization tests. 45243-K-CG was demonstrated to be a strong sensitizer; all animals reacting to 45243-K-CG also reacted to 5243-K-CG when rechallenged.
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