On the role of bradykinin in secretion from vascular endothelial cells
Emeis, J.J.; Tranquille, N.
Agents and Actions. Supplements 38: 285-291
1992
ISSN/ISBN: 0379-0363 PMID: 1334333 Document Number: 394587
Bradykinin will induce, in perfused rat hindlegs, the acute release from endothelial cells of tissue-type plasminogen activator and of von Willebrand factor. This release is mediated by B2-receptors, requires the influx of extracellular calcium, and is modulated by cyclic nucleotides. A possible role of bradykinin in the physiological regulation of plasma levels of tissue-type plasminogen activator is discussed.
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