Diagnostic value of C-reactive protein and D-dimer in deep venous thrombosis
Jøssang, B.; Runde, I.
Tidsskrift for den Norske Laegeforening Tidsskrift for Praktisk Medicin Ny Raekke 112(9): 1153-1155
1992
ISSN/ISBN: 0029-2001 PMID: 1579935 Document Number: 393433
The accuracy of C-reactive protein (CRP) and D-dimer in detecting deep venous thrombosis was compared with phlebography in a consecutive series of 69 patients admitted to hospital due to suspicion of thrombosis in the leg. With a sensitivity of 100%, C-reactive protein can exclude the possibility of thrombosis. The sensitivity of D-dimer was too low to exclude the diagnosis. With a high discrimination limit the specificity of D-dimer was 100%, which may confirm the diagnosis. Ideally, screening with C-reactive protein and D-dimer could reduce the need of venography by 38%.