Top Abstract Purchase Related
Home
>
Node
>
Subnode

Patterns of serological markers for cellular immune activation in patients with dilated cardiomyopathy and chronic myocarditis

Samsonov, M.; Fuchs, D.; Reibnegger, G.; Belenkov, J.N.; Nassonov, E.L.; Wachter, H.

Clinical Chemistry 38(5): 678-680

1992

ISSN/ISBN: 0009-9147
PMID: 1582019
Document Number: 393340
We determined serum concentrations of neopterin and beta 2-microglobulin, soluble markers of cellular immune activation, in 27 patients with either dilated cardiomyopathy (DCM) or chronic myocarditis. Neopterin and beta 2-microglobulin concentrations were respectively increased in 2 and 5 of 11 patients with DCM and in 11 and 9 of 16 patients with chronic myocarditis. A higher cardiac functional class (according to the New York Heart Association) was associated with greater neopterin and beta 2-microglobulin concentrations. During follow-up of patients, both neopterin and beta 2-microglobulin concentrations in serum correlated with the course of disease. Additionally, correlations were significant between left ventricular functional tests (end-diastolic volume, end-systolic volume, and ejection fraction) and neopterin and beta 2-microglobulin concentrations. We conclude that measurement of neopterin and beta 2-microglobulin are useful to monitor disease development in patients with myocardial inflammation.

Document emailed within 1 workday
Secure & encrypted payments

Kühl, U.; Daun, B.; Seeberg, B.; Schultheiss, H.P.; Strauer, B.E. 1992: Dilated cardiomyopathy--a chronic myocarditis? Immunohistological characterization of lymphocytic infiltrates Herz 17(2): 97-106
Higuchi, M.d.L.; Camargo, P.R.; Aiello, V.D.; Mazzieri, R.; Snitcowsky, R.; Fiorelli, A.; Ebaid, M.; Pileggi, F. 1990: Histologic response of the myocardium to various immunosuppressor schedules in patients with dilated cardiomyopathy and diagnosis of myocarditis at endomyocardial biopsy Arquivos Brasileiros de Cardiologia 54(5): 319-322
Bowles, N.E.; Richardson, P.J.; Olsen, E.G.; Archard, L.C. 1986: Detection of Coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy Lancet 1(8490): 1120-1123
Chen, H. 1992: On viral myocarditis and dilated cardiomyopathy Zhonghua Xin Xue Guan Bing Za Zhi 20(1): 3
Przybojewski, J.Z. 1985: Myocarditis and dilated (congestive) cardiomyopathy South African Medical Journal 67(14): 529-531
Amosova, E.N. 1990: Dilated cardiomyopathy and Abramov-Fiedler myocarditis Terapevticheskii Arkhiv 62(5): 127-130
Włodarska, E.K. 1991: The role of viruses in the pathogenesis of myocarditis and dilated cardiomyopathy Kardiologia Polska 34(4): 250-255
Jiang, J. 1992: Possible relationship between acute viral myocarditis and dilated cardiomyopathy Zhonghua Xin Xue Guan Bing Za Zhi 20(1): 4-6; 69
Branishte, T.A.; Kuznetzov, A.V.; Khuchua, Z.A.; Samko, A.N.; Naumov, V.G.; Semenovskiĭ, M.L.; Belenkov, I.N.; Saks, V.A. 1992: Cellular mechanisms of impaired cardiac energetics in patients with dilated cardiomyopathy: decrease in mitochondrial respiration and creatine kinase expression Kardiologiia 32(5): 13-16
Eerens, F.; Van Cleemput, J.; Peetermans, W.E. 1999: A probable primary HIV infection associated with acute non-specific myocarditis causing severe dilated cardiomyopathy Acta Clinica Belgica 54(4): 220-222
Strauer, B.E. 1995: Consensus conference. Myocarditis--dilated cardiomyopathy. Inaugurated by the German Society of Internal Medicine Der Internist 36(5): 484-502
Wasilewski, J.; Juszczyk, J.; Pasyk, S. 1991: Myocarditis and dilated cardiomyopathy in scintigraphic evaluation using gallium-citrate 67 and antimyosin antibodies radiolabelled with indium 111 Polski Tygodnik Lekarski 46(19-21): 389-390
Coughlin, S.S.; Myers, L.; Michaels, R.K. 1997: What explains black-white differences in survival in idiopathic dilated cardiomyopathy? the Washington, DC, Dilated Cardiomyopathy Study Journal of the National Medical Association 89(4): 277-282
Kubyshkin, V.F.; Mazurets, A.F.; Dziuba, M.V. 1991: The indices of the proteinase-peroxidase and phosphatase activities of the blood polymorphonuclear leukocytes in the differential diagnosis of dilated cardiomyopathy and idiopathic myocarditis Vrachebnoe Delo 4: 31-34
Arbustini, E.; Grasso, M.; Porcu, E.; Bellini, O.; Magrini, G.; Campana, C.; Rinaldi, M.; Pagani, F.; Viganò, M.; Tavazzi, L. 2001: Healing of acute myocarditis with left ventricular assist device: morphological recovery and evolution to the aspecific features of dilated cardiomyopathy Italian Heart Journal: Official Journal of the Italian Federation of Cardiology 2(1): 55-59
Ragna Arndt-Marić; Herbert Nägele; Schewe, G.; Kromminga, A. 2010: Are Autoantibodies Against the β1-adrenergic Receptor Markers for Dilated Cardiomyopathy? Clinical Laboratory 56(11-12): 519-526
Tereshchenko, S.N.; Alaeva, E.N.; Narusov, O.I.; Kochetov, A.G.; Safiullina, A.A.; Shchedrina, A.I.; Seredovich, V.V.; Zotova, L.A.; Skvortsov, A.A. 2012: Prevalence and diagnosis of dilated cardiomyopathy. Results of the registry of dilated cardiomyopathy in the Russian Federation Kardiologiia 52(7): 67-72
Shaposhnik, I.I.; Shaposhnik, O.D. 1992: The development of signs of dilated cardiomyopathy in patients with nonobstructive hypertrophic cardiomyopathy Terapevticheskii Arkhiv 64(11): 125-126
Van den Berg, A.P.; van Son, W.J.; Tegzess, A.M.; The, T.H. 1993: Cellular immune activation reflects antiviral immunity and is a favorable prognostic marker in patients with cytomegalovirus infection Transplantation Proceedings 25(1 Part 2): 1419-1420
Vianello, F.; Tison, T.; Tagariello, G.; Zerbinati, P.; Zanon, E.; Scarano, L.; Girolami, A. 1999: Serological markers of autoimmunity in patients with hemophilia A: the role of hepatitis C virus infection, alpha-interferon and factor VIII treatment in skewing the immune system toward autoreactivity Blood Coagulation and Fibrinolysis: An International Journal in Haemostasis and Thrombosis 10(6): 393-397