Short-duration bladder instillation therapy with pirarubicin for superficial bladder tumor based on pharmacodynamic study
Nakagawa, S.; Kojima, M.; Takada, H.; Sugimoto, K.; Mikami, K.; Watanabe, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 19(11): 1873-1877
1992
ISSN/ISBN: 0385-0684 PMID: 1519929 Document Number: 393041
From our experimental study, an instillation of THP for 5 minutes was attempted in 23 patients with superficial bladder tumors. THP (30 mg dissolved in 50 ml of distilled water) was instilled into the bladder 6 times every 48 hours. Of 23 patients, 9 (39%) showed complete disappearance of the bladder tumors, while partial disappearance (more than 50% tumor reduction) was observed in 3 cases (13%). Therefore the overall response rate was 52%. Neither urinary frequency nor hematuria was observed in all the cases, while painful urination was observed in 3 cases (13%). This newly designed bladder instillation therapy was effective against superficial bladder tumors with low incidence of local side effects.