Effects of gadolinium on N-methyl-D-aspartate (NMDA) -induced centrogenic arrhythmias
Berrino, L.; De Novellis, V.; Maione, S.; Cuparencu, B.; Rossi, F.
Research Communications in Chemical Pathology and Pharmacology 78(2): 219-223
1992
ISSN/ISBN: 0034-5164 PMID: 1362004 Document Number: 392186
In urethane-anesthesized rats, the intracerebroventricular (i.c.v) administration of N-methy-D-asparate (NMDA)-induced central arrhythmias. These cardiac rhythm disorders could be prevented by the i.c.v. microinjection of gadolinium, and inhibitor of exocytosis. These findings suggest taht inhibition of central neurotransmitter exocytosis could protect against centrogenic arrhythmias.
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