Effects in vitro of two marine substances, chlorolissoclimide and dichlorolissoclimide, on a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6)
Malochet-Grivois, C.; Roussakis, C.; Robillard, N.; Biard, J.F.; Riou, D.; Débitus, C.; Verbist, J.F.
Anti-Cancer Drug Design 7(6): 493-502
1992
ISSN/ISBN: 0266-9536 PMID: 1337432 Document Number: 391592
The antiproliferative activity of two nitrogenous labdane cytotoxic substances from Lissoclinum voeltzkowi Michaelson (Urochordata), dichlorolissoclimide (P2) and chlorolissoclimide (P1), was studied in vitro on a continuous human nonsmall-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. This antiproliferative effect resulted from a blockade of G1 phase cells. Mortality occurred, regardless of the degree of cell ploidy, with cell transition to an out-of-cycle situation characteristic of a G1D terminal maturation state.