Cortical bone remodeling in normal rat
Stenström, A.; Hansson, L.I.; Thorngren, K.G.
Calcified Tissue Research 23(2): 161-170
1977
ISSN/ISBN: 0008-0594 PMID: 890554 Document Number: 390
Cortical bone remodeling along the femur diaphysis was determined in normal female rats (Sprague-Dawley) with the tetracycline technique. Three segments on the cortical bone circumference (anterolateral, medial and posterior) were most suitable for the study of the remodeling process. Oxytetracycline [OTC] was administered at age 60 and 75 days, and groups of animals were killed at age 75, 85, 95 and 105 days. The accumulated endosteal growth during age 60-75 days in the anterolateral segment increased uniformly in the distal direction along the femur diaphysis. A method is described where this accumulated endosteal growth is used. This method eliminates the use of calipers to determine the section level and makes it possible to study comparable sections even after varying periods of time. The proximal part of the diaphysis showed periosteal apposition in all 3 segments. The periosteal apposition turned into resorption in the distal part of the diaphysis in the anterolateral and medial segments, but the periosteal apposition increased in the posterior segment. The endosteal growth increased in the distal direction in the anterolateral and medial segments. Irregular OTC bands made measurements of endosteal remodeling in the posterior segment impossible. The cortical width decreased in the distal direction along the femoral shaft. Comparison between the different age groups and the relation between the accumulated endosteal growth and the diameter of the medullary cavity are described.
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