Two weeks treatment with amoxicillin/omeprazole for eradication of Helicobacter pylori
Labenz, J.; Gyenes, E.; Rühl, G.H.; Börsch, G.
Zeitschrift für Gastroenterologie 30(11): 776-778
1992
ISSN/ISBN: 0044-2771 PMID: 1471383 Document Number: 389529
In an open study, 62 patients with Helicobacter pylori-associated ulcer disease or functional dyspepsia were treated for two weeks with 2 times 20 mg omeprazole preprandially and 4 times 500 mg amoxicillin suspension one hour before meals and at night. 57 patients (active ulcer disease: n = 53, functional dyspepsia: n = 4) completed the study without contravening the protocol. The rate of eradication of the bacteria at least 4 weeks after cessation of study medication was 82.5% (47/57 patients). Three patients experienced side effects during the treatment peroid (stomatitis, selflimiting diarrhea, allergic exanthema). In one case allergic exanthema led to discontinuation of therapy. 11 patients with H. pylori-associated ulcer disease received 2 times 20 mg omeprazole for two weeks. In this group no eradication of bacteria was observed.