Comparative electrophoretic characteristics of alkaline phosphatase isoforms in maternal blood and shaggy chorion extracts at various periods of pregnancy
Tsymbalova, T.A.; Tsirel'nikov, N.I.
Biulleten' Eksperimental'noi Biologii i Meditsiny 114(9): 236-238
1992
ISSN/ISBN: 0365-9615 PMID: 1477340 Document Number: 389513
A comparative study of enzyme alkaline phosphatase (AP) of plasma and chorion placental extracts was made in various terms of pregnancy by PAAG electrophoresis. It is shown that the first three month chorion extract contained 1 thermolabile (TL) and 1 or 3 thermostable (TS) fractions of AP. In the second trimester of intrauterine development the activity of TL fraction disappeared, the number of TS forms increased. The early plasma period (6-12 weeks) was characterized by 2 TL non-placental forms, from the second half they added to 1 or 3 TS placental fractions, and before delivery TS enzyme appeared in the liver AP which had no analogue in the placenta. It is concluded that only the fastest placental TS AP forms (1 or 3) appear in maternal blood from the second trimester of gestation.