Propofol to provide sedation after coronary artery bypass surgery. a comparison of two fixed rate infusion regimens
O'Connor, M.; Stow, P.; Mortimer, A.; Fisher, A.; Sear, J.W.
Acta Anaesthesiologica Belgica 43(4): 235-241
1992
ISSN/ISBN: 0001-5164 PMID: 1300857 Document Number: 389090
Propofol (2,6, di-isopropylphenol) was given by continuous intravenous infusion to provide sedation following coronary artery bypass surgery. The need for additional sedation, analgesia and hypotensive agents was assessed at two propofol infusion rates (10 or 25 micrograms/kg/min). Both rates provided clinically satisfactory conditions. There were no differences in the requirements for analgesia or vasodilators between the groups. The higher infusion rate of 25 micrograms/kg/min was associated with a lower requirement for additional sedation but a more frequent need to stop the infusion temporarily to prevent hypotension.