Disseminated histoplasmosis diagnosed by percutaneous needle biopsy of a retroperitoneal lymph node. A case report
Neumann, M.P.; Eng, M.H.; Rholl, K.S.; Swedo, G.J.; Meranze, S.G.
Acta Cytologica 36(4): 527-528
1992
ISSN/ISBN: 0001-5547 PMID: 1636347 Document Number: 388889
A case of disseminated histoplasmosis diagnosed by percutaneous needle biopsy cytology is reported in a 48-yr-old HIV-positive man. The patient presented with fever and pancytopenia and CT revealed retroperitoneal lymphadenopathy. Cytology smears prepared from a CT-guided screw needle biopsy of one of the lymph nodes showed numerous histiocytes with intracytoplasmic yeast forms consistent with Histoplasma capsulatum. Fungal cultures prepared from additional needle biopsy material confirmed the diagnosis. The patient was promptly treated with ketoconazole and a dramatic clinical response was noted. CT one month later showed resolution of retroperitoneal lymphadenopathy.