Role of oxygen free radicals in the physiopathology of rheumatoid arthritis
Laurindo, I.M.; de Mello, S.B.; Cossermelli, W.
Revista do Hospital das Clinicas 47(1): 38-45
1992
ISSN/ISBN: 0041-8781 PMID: 1307402 Document Number: 388852
The authors present a review of the mechanisms of free radicals production and report the results of "in vivo" and "in vitro" studies correlating these agent with the physiopathologic changes of the rheumatoid arthritis. The data reviewed in this paper support the idea of the participation of free radicals in the articular lesion. However new studies are necessary to determine the contribution of free radicals on disease development, chronicity and the efficacy of antioxidant agents.