Analysis of the genetic predisposition to cancer in families of patients with multiple primary malignant neoplasms
Gar'kavtseva, R.F.; Kazubskaia, T.P.; Sel'chuk, V.I.
Tsitologiia i Genetika 26(2): 32-36
1992
ISSN/ISBN: 0564-3783 PMID: 1615556 Document Number: 388832
Clinical-genetic examination of 305 patients with multiple primary tumors aimed at determining the rate of genetic burden to their development and community of joint accumulation of tumors in families of these patients has revealed a significant genetic community of inheritance of breast cancer, carcinomas of colon, endometrium, ovaries and stomach in the families of patients with multiple primary tumors. Comparative analysis of genetic correlations has shown the greatest genetic burden in families of patients with multiple primary tumours as against the families of patients with solitary cancer.