Application of transgenic model in renal research
Doi, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 50(12): 2849-2854
1992
ISSN/ISBN: 0047-1852 PMID: 1491441 Document Number: 388279
In the present report, we have used transgenic models to analyze the role of growth factors in the development of glomerulosclerosis. All peptides inducing a growth response do not lead to glomerulosclerosis, however, several transgenic models including growth hormone, transforming growth factor-a or SV 40T antigen developed progressive glomerulosclerosis, which was associated with glomerular hypertrophy. Evidence obtained from these transgenic models suggests that glomerulosclerosis may be related to a dysregulation of glomerular cell growth and a synthesis of extracellular matrix components by resident glomerular cells.