Null cell adenoma of the pituitary with features of plurihormonality and plurimorphous differentiation
Kontogeorgos, G.; Horvath, E.; Kovacs, K.; Killinger, D.W.; Smyth, H.S.
Archives of Pathology and Laboratory Medicine 115(1): 61-64
1991
ISSN/ISBN: 0003-9985 PMID: 1987915 Document Number: 387730
The case of a 35-year-old man with pituitary macroadenoma who was complaining of reduced sexual activity is presented. Histologic examination showed a chromophobic adenoma corresponding mainly to a null cell adenoma at the ultrastructural level. Focal plurihormonality and plurimorphous differentiation of adenoma cells were demonstrated by immunohistochemical and electron-microscopic studies. It is suggested that adenomatous null cells represent pluripotent progenitor cells capable of transforming to different hormone-producing cell types. The factors accounting for differentiating to various cell populations have yet to be elucidated.