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The activity of etoposide (VP16) in combination chemotherapy against human bladder cancer cells in vitro

Hattori, T.; Satoh, M.; Terashima, Y.; Nishimura, T.; Akimoto, M.

Hinyokika Kiyo. Acta Urologica Japonica 37(9): 995-998

1991

ISSN/ISBN: 0018-1994
PMID: 1785427
Document Number: 387208
The activity of Etoposide (VP16) in combination chemotherapy against four human transitional cell carcinoma cell lines of bladder (TCCaB) was determined by in vitro colony formation assay. Four anti-tumor agents (methotrexate: MTX, vinblastine: VBL, adriamycin: ADM, cisplatin: DDP) were used for combination chemotherapy with VP16. The ADM + VP16 combination exhibited a strong synergistic antitumor effect against the human TCCaBs compared with other combinations in this study. The combination chemotherapy of ADM + VP16 may be useful as a new chemotherapeutic regimen for advanced bladder cancer.

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