Experimental substantiation of MPEL of 3-phenoxybenzyl chloride in water reservoirs
Shtabskiĭ, B.M.; Fedorenko, V.I.; Siarchinskiĭ, I.I.; Avgustinovich, M.S.; Khoma, O.A.; Tomkiv, V.M.
Gigiena i Sanitariia 2: 16-19
1991
ISSN/ISBN: 0016-9900 PMID: 2055503 Document Number: 387005
On the basis of experimental studies it was established, that the threshold concentration of 3-phenoxybenzyl chloride (PBC) according to the influence on organoleptic water properties (odour) is 0.03 mg/l, on the sanitary regimen of water reservoirs (BOD inhibition)--0.3 mg/l. The chemical produces low toxicity when administered parenterally, it is highly toxic when administered subcutaneously; cumulation degree is medium. PBC produces a weak allergic effect, an expressed embryotoxic effect; mutagenic activity was not detected. The maximal no-effect dose according to the embryotoxic effect is 0.12 mg/kg (2.4 mg/l), the calculated maximal no-effect concentration is 0.11-0.34 mg/l when administered subcutaneously. The recommended MAC is 0.03 mg/l according to the organoleptic index of harmfulness (odour) with a note 'dangerous when administered through skin' (the third class of danger).