Use of chloral hydrate for assessing the detoxifying function of the liver in experimental pathology
Riabinin, V.E.; Lifshits, R.I.
Voprosy Meditsinskoi Khimii 37(5): 52-53
1991
ISSN/ISBN: 0042-8809 PMID: 1759398 Document Number: 385895
A new procedure, developed for evaluation of the liver tissue detoxicating activity in experimental pathology, involved estimation of chloral hydrate pharmacological efficiency and registration of animal sleep duration. As activity of uridine phosphate glucuronyl transferase, the key enzyme of the second step of biotransformation, was found to be inhibited after thermic burns, treatment of the disease using phenobarbital appears to correct the enzymatic activity.