Interrelation of xanthine oxidase and dehydrogenase and L-gulonolactone oxidase in animal tissues
Nandi, A.; Chatterjee, I.B.
Indian Journal of Experimental Biology 29(6): 574-578
1991
ISSN/ISBN: 0019-5189 PMID: 1889832 Document Number: 385625
There is a correlation between phylogeny and the activities of L-gulonolactone oxidase (LGO), the key enzyme responsible for ascorbic acid (AH2) synthesis in animals and total xanthine oxidase and dehydrogenase [XOD(D/O)], the enzyme responsible for the production of endogenous superoxide radical (O2-.). LGO appears in the kidneys of amphibians and reptiles but livers of mammals. XOD(D/O) also is present mainly in the kidneys of amphibians and reptiles and livers of mammals. AH2 is a potential scavenger of O2-. and it appears that tissue specific expression of LGO takes place to counteract the endogenous O2-. toxicity. The interrelation of XOD(D/O) and LGO was also observed in the liver of rats during prenatal to postnatal development.