Autoimmune hemolytic anemia associated with severe giant cell hepatitis
Camarero Salcés, C.; Vasconez Muñoz, F.; San José Hernando, D.; Morales, P.; Suárez Cortina, L.; Parra Vázquez, C.; Escobar Castro, H.; Muñoz Villa, A.
Anales Espanoles de Pediatria 34(2): 149-151
1991
ISSN/ISBN: 0302-4342 PMID: 2042809 Document Number: 384863
Autoimmune hemolytic anemia and severe giant cell hepatitis is an very uncommon association. Two patients aged 5 months and 2 years developed severe anemia, jaundice, hepatomegaly and splenomegaly. Laboratory tests demonstrated autoimmune hemolytic anemia and elevated amino-transferases. Diffuse giant cell transformation and distorted architecture was seen in liver biopsy. One patient had a cytomegalovirus infection. Early steroid therapy did not prevent fatal course with liver failure in one patient.