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Restriction fragment length polymorphisms, glucocorticoid receptors, and phenytoin-induced cleft palate in congenic strains of mice with steroid susceptibility differences

Gasser, D.L.; Goldner-Sauvé, A.; Katsumata, M.; Goldman, A.S.

Journal of Craniofacial Genetics and Developmental Biology 11(4): 366-371

1991

ISSN/ISBN: 0270-4145
PMID: 1687470
Document Number: 384833
A gene that affects susceptibility to cortisone-induced cleft palate maps between H-2S and H-2D on mouse chromosome 17. Congenic mouse strains that differ at this locus, designated Cps-1 (cleft palate susceptibility-1), have been tested for the presence of several closely linked markers. All data obtained so far are consistent with a gene order of H-2S-Cps-1-BAT-5-BAT-2-TNF-H-2D. The Cps-1 gene does not appear to affect the level of glucocorticoid receptors or the susceptibility of mice to phenytoin-induced cleft palate.

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