MHC class i restricted T cells and immune surveillance against transplanted ultraviolet light-induced tumors
Ward, P.L.; Schreiber, H.
Seminars in Cancer Biology 2(5): 321-328
1991
ISSN/ISBN: 1044-579X PMID: 1837738 Document Number: 384811
Studies involving tumor escape from host immune surveillance have focused heavily on loss of major histocompatibility class I antigens as well as loss of tumour-associated antigens as possible mechanisms by which tumors escape recognition and lysis by cytolytic T cells. Examples of both phenomena are found in murine tumors induced by viruses, chemical mutagens, a spontaneous tumor mutagenized in vitro and some u.v.-induced tumors. However, evidence also exists for the escape of tumors from immune destruction without loss of major histocompatibility class I molecules or tumor antigens and additional mechanisms undoubtedly are involved in the complex phenomena of tumor progression.